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Results: PA administration showed beneficial effects on APAP-induced hepatotoxicity through improvements in liver functions, decreased CYP2E1 gene expression, decreased serum and liver iron load, decreased MDA, increased GSH, increased SIRT -1 expression level and improvement in hepatic architecture

Consistent with these pathological findings, both semaglutide and tirzepatide significantly lowered liver triglycerides (TG) and total cholesterol (TC) (Fig.4-C, D)

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