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Animal studies by Carla Nasca, a postdoctoral scholar in McEwens lab, suggest that acetyl-L-carnitine, a crucial mediator of fat metabolism and energy production throughout the body, plays a special role in the brain, where it works at least in part by preventing the excessive firing of excitatory nerve cells in brain regions called the hippocampus and frontal cortex

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Furthermore, an oral intake of 250 mg NMN once daily in the afternoon for 12 weeks effectively improved physical performance and fatigue in elderly people over 65 years old [190]