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Recent studies have shown that glutamine deprivation can inhibit cholesterol synthesis in hepatocellular carcinoma (HCC) by inducing lipid autophagy, thereby reducing NADPH consumption during cholesterol synthesis and maintaining redox balance

Taking these drawbacks into consideration, the prodrugs of EGCG analogs were synthesized with the compounds identified as 2a and 4a having lower susceptibility to be metabolized or inhibited by COMT and having an amplified antiproliferative, antiangiogenic, and antifibrotic effect in HuLM (Ahmed et al., 2016)

168 Additionally, senescent neutrophils can accumulate at pre-metastatic sites for lung metastasis in breast cancer patients, forming neutrophil extracellular traps that effectively ensnare tumor cells and facilitate lung metastasis

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