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Notably, clinical observations indicate that endocrine therapy resistance is closely associated with oestrogen-dependent redox signal dysregulation mediated by ROS, suggesting that targeting ROS homeostasis may represent a novel breakthrough for reversing drug resistance [127]

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The article says it can

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Laser Treatment Laser treatment is FDA-cleared and can help circulate the blood flow in the swollen area

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Constipation lasted for a median duration of 35 days for these patients, but was the least common side effect and was usually reported as mild

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Patients with uneven pigmentation, sun damage or dull skin tone may consider these therapies

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