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Mutations in the Casitas B-cell lymphoma (Cbl)-binding domain are demonstrated to be oncogenic because binding of Cbl to Y1003 causes Met ubiquitination that is vital to maintenance of physiological Met activation and prevention of continued activation of Met (Peschard and Park, 2007)

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Under normal physiological conditions acetylcholine stimulates nicotinic acetylcholine receptors on skeletal muscle to open an ion channel that allows calcium influx to cause muscle contraction

Oxidative stress: correlation with Behet's disease duration, activity and severity