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Ranim M, Virginia K, Merlin GB

Both lightly and darkly pigmented skin contain similar numbers of melanocytes, [12] with difference in skin color due to differences the packing of eumelanin into the melanosomes of keratinocytes: those in dark-toned skin are "packaged into peri-nuclear distributed, ellipsoid" melanosomes while those light-tone skin are "assembled into clustered small, circular melanosomes"

It is associated with sporadic CRC in early age, and its polymorphisms, such as L503F, may help to predict malignant progression of the disease in IBD patients (Martini et al., 2012)

The most common injury or condition of the knee is tendinitis