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Adherence is another major issue one study suggested that roughly two-thirds of patients discontinue GLP-1 therapy within the first year, often due to high costs, gastrointestinal side effects, lack of perceived benefit, or difficulty maintaining lifestyle changes

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In order to select the appropriate model, we employed an objective function comprised of specificity values, the proportion of true negatives identified within decoys excluded from training, the percentage of active compounds identified from the family, and the percentage of compounds from the binding database not associated with the family, then we established an ML model for each family, as delineated in Table 4

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