We do not know what fraction reaches systemic circulation in humans, and "detectable GI effect" does not equal "adequate systemic bioavailability for joint repair." The acetate salt versus free acid labeling problem
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Changes in lipid and lipoprotein metabolism were not detected in cardiac MTs using DEGs, but similar effects of DMSO were observed for citric acid cycle and respiratory electron transport (q-value: 1.3 * 10 12 , 58 DEGs out of 171 genes, 65.5% downregulated) and glucose metabolism (q-value: 2.8 * 10 3 , 20 DEGs out of 77 genes, 55.0% downregulated), though less genes were downregulated in cardiac MTs compared to hepatic MTs
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Patients may be advised to eat smaller, more frequent meals, avoid high-fat or high-fiber foods, and focus on easily digestible options