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The dulaglutide result probably generalizes, but nobody has confirmed it

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In vitro systems are useful for identifying key metabolic nodes and their threshold effects, but differences in amino acid concentrations in culture media, stimulation conditions, and criteria for polarization assessment may all affect the extrapolatability of the conclusions

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Building on this mechanistic foundation, we examine how these shared pathogenic principles manifest distinctly in major neurodegenerative diseases, while also discussing representative mitochondrial optic neuropathies as tractable disease models that have yielded critical mechanistic and therapeutic insights