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This flexibility in administration routes offers practical advantages for addressing injuries in different body locations

Unlike native -MSH, which has a very short plasma half-life due to rapid enzymatic degradation, MT-1 incorporates a linear sequence modification that significantly extends its stability in biological matrices while preserving high-affinity binding at melanocortin receptors primarily MC1R, the receptor responsible for eumelanin synthesis in melanocytes

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Advantages: Dual route: injectable for deep joints, topical for superficial joints

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