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Although we were unable to assess blood drugs levels in the TriNetX database, the consistent reduction in MAKEs observed in steroid, tacrolimus and cyclosporine subgroups provides indirect reassurance of the safety of GLP-1 RAs in KRTs and regardless of the specific immunosuppressive regimen

12 International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (2023) ICH M7(R2) Guideline on assessment and control of DNA reactive (mutagenic) impurities in pharmaceuticals to limit potential carcinogenic risk

Collectively, these findings underscore how DrugHerb Interactions operate through multi-targeted mechanisms to offer promising integrated medical approaches for cardiometabolic disease management