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Moreover, alterations in gut microbiota structure or imbalance can contribute to metabolic disorders, influencing the synthesis of purine-metabolizing enzymes and the release of inflammatory cytokines

Magnoflorine inhibited p65 and IkB, which in turn inhibited the activation of NF-B and the phosphatidylinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway, exerting anti-inflammatory effects and inhibiting the release of IL-6, IL-8, iNOS and COX-2 to subsequently reduce the inflammatory response

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In conclusion, this study demonstrated that intra-articular injections of AOD9604 improved cartilage health and functional recovery in a rabbit OA model