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These limitations have motivated sustained efforts to develop orally available non-peptidic GLP-1R agonists

Topiramate's effect on weight reduction and long-term maintenance of body weight may be due to its effects on both appetite suppression and satiety enhancement, induced by a combination of pharmacologic effects including augmenting the activity of the neurotransmitter gamma-aminobutyrate, modulation of voltage-gated ion channels, inhibition of AMPA/kainite excitatory glutamate receptors, or inhibition of carbonic anhydrase

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One case involved a woman who relapsed into full anorexia after a decade of recovery following the prescription of a GLP-1 medication for an unrelated metabolic condition