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Possible improvements in insulin sensitivity : Some small studies suggest creatine combined with exercise may enhance glucose uptake, though direct glycaemic effects remain uncertain and require further investigation in larger, well-designed trials

Increases in embryo-fetal resorptions and post-implantation losses were observed at 0.1 mg/kg/day in the presence of significant maternal toxicity, and fetal body weights were 7% lower than controls at 0.2 mg/kg/day

Pre-conception weight optimization improves not only conception rates but also pregnancy outcomes and gestational health

It is typically most pronounced during dose escalation and tends to diminish as the body adapts over 4 to 8 weeks

However, the initial FDA submission is for obesity only