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Low GSH levels associate with metabolic syndrome, cardiovascular disease, chronic kidney disease, NAFLD/NASH, Parkinsons disease, Alzheimers disease, autoimmune conditions, HIV infection, and cancer

30 Relationship of S-adenosyl-L-Methionine and Glutathione The metabolism of GSH and S-adenosyl-L-methionine (SAM) are closely linked, as the liver forms GSH as a product of SAM metabolism (Figure 4)