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In preclinical studies, the peptide activated melanocortin receptors in the medial preoptic area, leading to increased dopamine signaling and enhanced sexual motivation

It has been reported that some compounds, once transformed into glutathione S -conjugates, enter the mercapturic acid pathway whose end products are highly reactive and toxic for the cell responsible for their production

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NVU astrocytes have versatile roles, supporting vascular endothelium, responding to immune stimuli, forming endfeet and the glia limitans, and regulating intracerebral fluid flow