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The MTHFR gene variant is carried by approximately 40% of the population and impairs conversion of folic acid to active methylfolate

Nonclinical studies in rodents of clinically relevant doses of GLP-1 receptor agonists showed dose-related and treatment-duration-dependent increases in the incidence of thyroid C-cell tumors (adenomas and carcinomas)

Nutr Diabetes 12 , 35 (2022)

This study established the core evidence that drives current research interest and it is important to note that this is primarily a preclinical (mouse) evidence base