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Tendons and ligaments have limited blood supply compared to muscle

The value of the combo lies in **mechanistic divergence coupled with vascular convergence**: BPC-157 covers local cytoprotection and the gut-tendon axis, TB-500 covers systemic cell migration and stem-cell mobilization, and both converge on the neoangiogenesis required for deep tissue regeneration

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This angiogenic effect appears to work through the upregulation of vascular endothelial growth factor (VEGF) and other growth factors critical for tissue repair

These findings align with previous research demonstrating the therapeutic potential of natural products like Cinnamaldehyde, Sarsasapogenin-AA13, Ginkgo biloba extracts, and active components of Andrographis paniculata in targeting these pathways for AD treatment [49, 89,90,91,92]