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Individual metabolic rates can vary greatly, influenced by factors such as age, gender, liver health, and genetic predispositions

Indeed, there may be synergy between FGF-21 and GCG receptor agonism, due to their similar metabolic actions, particularly related to brown adipose tissue differentiation and activation [32], with FGF21 having additional actions in the liver, reducing hepatic lipogenesis and enhancing hepatic insulin sensitivity [66, 67]

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These processes promote the establishment of apical and basal membrane domains