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Additionally, in SH-SY5Y neuroblastoma cells, exendin-4 treatment upregulates the mitochondrial quality control regulators Parkin and PTEN induced kinase 1, reduces Bax expression, enhances Akt and Bcl-2 levels, and inhibits tumor cell apoptosis (83)

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Finally, pro-caspase 9 has been shown to get activated by mitochondrial cytochrome c (which has been shown to be increased in ES) [204] also linking oxidative stress and mitochondrial functioning to apoptosis

Your dose may need to go up as you progress in treatment

Apply PLU peptides first on clean skin, wait for absorption, then layer other actives or moisturizers as desired to maintain research-aligned efficacy