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In the SURMOUT-1 trial 2,539 patients underwent randomization to tirzepatide or placebo and were followed for 72 weeks demonstrating up to 20.9% weight reduction with maintenance dosing versus 3.1% in the placebo group for a net 17.8% weight reduction [35]

doi: 10.1124/jpet.104.081968

In the current study, we found that all of the patients had a reduction in expected walk distance (some very severe)

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Fortunately, recent studies have shown that many active compounds found in natural drugs have promising therapeutic effects on depression and anxiety and are considered highly safe (Wu et al., 2022