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Because GLP-2 acts through subepithelial myofibroblasts, which are the same cell population implicated in intestinal fibrogenesis, the risk-benefit profile of GLP-2 agonism may differ substantially between mucosal UC, inflammatory ileal CD, and stricturing or penetrating CD phenotypes, and this phenotypic stratification should be a required feature of future trial design

These clips are pretty dramatic, though to maintain the results requires frequent infusions

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TB4 (Thymosin Beta-4) is a naturally occurring peptide found throughout the body that regulates actin dynamics, recruits stem cells and progenitor cells to injury sites, reduces inflammation, and drives new blood vessel formation