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Inclusion criteria require patients aged 18 and older with clinical UC diagnosis, moderate to severe active disease (mMS 5 with MES 2), recent surveillance colonoscopy ruling out dysplasia or cancer, and history of inadequate response or intolerance to at least 2 UC therapy classes, while excluding those with CD, fulminant colitis, disease limited to rectum, prior colectomy plans, or previous PD-1/PD-L1 exposure

Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain