tirzepatide semaglutide mechanism of action of tirzepatide GIP = glucose-dependent insulinotropic polypeptide; GLP-1 = glucagon-like peptide 1; LDL = low-density lipoprotein; HR = heart rate Semaglutide vs. Tirzepatide: What's the

See our unit conversion reference for both protocol types

You learn that added benefit can include superior weight loss, improved glycemic control, or a reduction in cardiovascular events for patients with type 2 diabetes

Current NICE guidance continues to position metformin as the initial treatment for most adults with type 2 diabetes, reserving GLP-1 agonists for specific situations rather than universal first-line use

These services are available to assist practitioners: Useful support services: Pharmacotherapy Area-Based Networks (PABN) Drug and Alcohol Clinical Advisory Service (DACAS) Pharmacotherapy Advocacy, Mediation and Support (PAMS) Let's continue to support one another, share knowledge, and ensure our patients remain at the centre of every clinical decision as we navigate this transition together

Semaglutide has a longer elimination half-life than tirzepatide