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The oral bioavailability is roughly 1%, which is why the oral doses (3 mg, 7 mg, 14 mg daily) appear higher than the injectable doses but deliver similar systemic exposure

BMC Genomics 14:

The medical encounters that researchers looked at included: being diagnosed with tobacco use disorder being prescribed a medication to help with smoking cessation having smoking cessation counseling during the study period For their analysis, researchers examined health records for 222,942 smokers with type 2 diabetes who used seven types of anti-diabetes medications

More BAC water means a more diluted solution and a larger draw per dose (easier to measure)

One study was categorized as having an unclear risk of attrition bias Three studies were classified as having an unclear risk of other forms of biases