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2001 in Endocrinology showed reduced body weight gain with 14-day AOD-9604 in obese (ob/ob) mice and identified the beta-3 adrenergic receptor dependency

Beaulieu J-M (2011) Beyond cAMP: the regulation of Akt and GSK3 by dopamine receptors

The DSPC analysis was based on a least absolute shrinkage and selective operator (LASSO) algorithm, and revealed significant functional correlations in valine, leucine, and isoleucine biosynthesis ( p = 8.59E-9) and degradation ( p = 7.91E-5), aminoacyl-tRNA biosynthesis ( p = 1.94E-4), fatty acid biosynthesis ( p = 0.018), and phenylalanine, tyrosine, and tryptophan biosynthesis ( p = 0.048) (Supplementary Figure 4)

Hartl L, Semmler G, Hofer BS, et al