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To mitigate IGF-1 side effects such as joint pain, swelling, and nerve compression, bodybuilders can follow several strategies: use the lowest effective dose under medical supervision, rotate injection sites, maintain proper hydration, support joints with supplements like glucosamine or omega-3 fatty acids, and incorporate stretching and mobility exercises

Similar to these studies, there are studies in which vitamin C (Reference Savran, Cicek and Doguc7) , resveratrol (Reference zgmen and Yeilot44) , quercetin (Reference Yuksel, Yuksel and Yagmurca45) , berberine (Reference Mehrzadi, Fatemi and Esmaeilizadeh48) and gallic acid (Reference Olayinka, Ore and Adeyemo43) were used to treat MTX-induced tissue damage

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PMID: 28819546