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This is when practitioners typically decide whether to continue, adjust dose, or discontinue

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175 REMOVAL (Reducing with Metformin Vascular Adverse Lesions) trial which is one of the longest and largest trials of metformin treatment within type 1 diabetes patients reported a small but sustained reduction in LDL cholesterol and weight in middle-aged adults over 3 years

The evaluation did not find evidence that these medications cause suicidal thoughts or actions

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