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Airway expression of calcitonin gene-related peptide in T-cell peptide-induced late asthmatic reactions in atopics

Research suggested that this lipolysis peptide may potentially facilitate the release of fat from adipose tissue while moderating the accumulation of new fat deposits in laboratory models, without appearing to alter caloric intake or appetite or adversely affect insulin sensitivity in these experimental settings

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Under constant exposure, receptors are pulled off the cell surface and become less responsive over time (receptor desensitization). Higher doses maintain more signal against that fade