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This effect is parallel with the effect on the peripheral blood vessels presentation

Our research indicates that myofibroblast markers, such as alpha smooth muscle actin (-SMA), are more prevalent in fibroblasts from aged mouse lungs compared to younger controls (Figure 3), highlighting the age-dependent increase in fibrosis susceptibility

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They hyperpolarize neurons in mood-regulating brain regions, essentially making those neurons harder to activate

The pooled effect size was homogenous ( I 2 = 0%) (Fig