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Certain MRPs have shown promise in contributing to the prevention of cancer and may positively influence glucose metabolism and cardiovascular health by potentially reducing cholesterol and triglyceride levels, inhibiting ACE activity, and exhibiting antithrombotic effects 36,37

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A previous study reported that vitamin C could prevent monosodium iodoacetate (MIA) induced changes such as cell growth inhibiting and oxidative stress increasing, apoptosis, MMPs increasing, and proteoglycan loss in a chondrosarcoma cell line (SW1353) [160]

In the phase III clinical developmental programs of the DPP-4 inhibitors, non-inferiority was demonstrated after 1 and 2 years for these substances compared to sulfonylureas with respect to the glycaemic parameters HbA1c as well as fasting- and post-prandial plasma glucose concentrations