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Common criteria include failed trials of oral diabetes medications, documented BMI thresholds (often 30+), and baseline metabolic or cardiometabolic risk factors

thetaiotaomicron creates competition by using a surface-exposed lipoprotein, which binds cobalamin with such affinity that can remove it from intrinsic factor, a cobalamin transport protein necessary for absorption in humans and animals [14]

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Most participants who experienced nausea during the initial titration phase reported significant improvement or complete resolution by weeks 4 to 8 at a stable dose

[DOI] [PubMed] [Google Scholar] 16.Bretault M, Carette C, Zaharia R, Vychnevskaia K, Bouillot JL, Czernichow S, Raffin-Sanson ML