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This yields a higher average force over the entire actuation stroke, which, in turn, yields a higher average stopper velocity and a reduction in delivery time

Common gastrointestinal effects reported with GLP-1 therapy include: Nausea (commonly reported, especially during dose escalation) Constipation or diarrhoea Abdominal discomfort or bloating Reduced appetite and early satiety Regarding bowel movement colour specifically, changes in stool colour are not listed as adverse effects in UK SmPCs for GLP-1 receptor agonists

Sorensen et al., 2015

Targeting 0.5 to 1% body weight loss per week rather than aggressive deficits protects lean mass

The only side effects sometimes noted at these higher amounts are minor digestive complaints like bloating, which typically go away on their own