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In addition, mechanistic toxicological studies are also warranted

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Such evidence points to a profile of sustained efficacy, compatible with long-term safety, a fact corroborated by economicmodelingstudiesthatconfirmthecost-effectiveness of tirzepatide use compared to available pharmacological alternatives (Hwang et al., 2025)

Mineralization of soft tissues occurs under pathological conditions and has detrimental consequences, particularly when it occurs in blood vessels and heart valves