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Sep 2017;31(9):1316-1322

doi:10.1016/j.plaphy.2013.05.032

While necessary, this phase transforms toxins into "reactive intermediate metabolites" that are frequently more toxic and volatile than the original substance, generating massive amounts of free radicals

Apart from this, the competition between NADPH-dependent enzymes in inflammatory versus antioxidative pathways can also be revealed by blocking the function of G6PD under inflammatory conditions as the output of both pathways will be impaired