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The insulin signaling pathway, critical for glucose regulation, begins with insulin binding to its receptor, which activates insulin receptor substrates (IRS) and recruits phosphoinositide 3-kinase (PI3 K), which turns phosphatidylinositol-4,5-bisphosphate (PIP 2 ) into phosphatidylinositol-3,4,5-trisphosphat (PIP 3 )

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Neuropsychopharmacology 36 , 529538 (2011)

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Subgroup analyses will evaluate the effects of adjunctive cigarette smoking cessation medications while controlling for potential confounders (age, BMI, diabetes duration, etc.)