Exendin-4 is a GLP-1 analogue derived from the salivary glands of the Gila monster lizard 13
The current restrictions, put in place in 2023, effectively banned compounding pharmacies from legally dispensing these substances, citing safety concerns and insufficient data
these medications may need dose adjustment Increased heart rate, typically a modest elevation Dehydration risk, especially with persistent vomiting or poor fluid intake, which can lead to acute kidney injury According to MHRA guidance, rare but serious adverse effects include acute pancreatitis (inflammation of the pancreas), gallbladder disease including cholelithiasis (gallstones), and thyroid C-cell tumours (observed in rodent studies
It is also important for patients to stay hydrated and maintain a healthy diet to reduce the risk of gastrointestinal symptoms
Navigating IBS or adapting to GLP-1 therapy can disrupt your gut microbiome, leading to irregularity, bloating, and daily discomfort