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The exact mechanism by which these medications cause headaches is not fully established, but several plausible theories exist

In This Review Overview Losing weight is hard

Symptom Relief: Alleviates symptoms of migraines, hangovers, or chronic fatigue

Patients with severe metabolic dysfunction may show slower early response (weeks 6-8) as their body corrects underlying insulin resistance, while those starting with better baseline metabolic markers often see results by week 4

For beginners, it's advisable to start at the lower end (2040 mcg/day) to assess tolerance and minimize side effects (Siddle, Growth Hormone & IGF Research )