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Combining these medications may increase the risk of side effects, including rapid heart rate, high blood pressure, nausea, and dehydration

AOP Development Strategy Context Used to provide background information for AOP reviewers and users that is considered helpful in understanding the biology underlying the AOP and the motivation for its development.The background should NOT provide an overview of the AOP, its KEs or KERs, which are captured in more detail below

Prospective cohort studies have reported that vitamin C intake from supplements (161, 162) or vitamin E intake from food and supplements (161) was associated with some protection against cognitive decline

The effect remains gradual and cumulative rather than instant

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