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This is especially true if you have autoimmunity, heavy metal overload, or another chronic illness

Using in vivo microdialysis, extracellular GSH levels of about 2 M were reported for rat brain, which are low when compared with blood plasma levels of 520 M (Yang et al., 1994

The trials behind oral glutathione used 250mg to 500mg a day not multi-gram "mega doses." One study testing a large 3-gram single dose found it didn't meaningfully raise blood glutathione levels at all