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FIGURE 1 Platinum accumulation in dorsal root ganglia The accumulation level of Pt drugs in DRG is 1020 times higher than that in other nerve cells, which could be attributed to the high expression of Pt-related transporters (e.g., Ctr1/2, OCTs) in DRG ( Among these transport proteins, Ctr1, composed of three highly conserved methionine (Met)-rich motifs, is involved in the transport of CP as a channel-like transporter ( 3 ) 2 ] intermediate, which induces a conformational change in Ctr1 and allows CP to pass laterally through the axis of the trimeric Ctr1 channel and move inward via the intermolecular sulfursulfur process exchange ( In addition, OCTs (e.g., OCT1 and OCT2), as the active transport proteins, mediate the endocytosis and efflux of organic cations driven by intramembrane negative potentials

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Cancer Cell Int