Possible complications heart failure severe neurological deficits gastric cancer type 1 diabetes rheumatoid arthritis myasthenia gravis (a chronic condition causing muscle weakness) Hashimotos disease (an autoimmune condition affecting the thyroid) A pregnant or nursing person with a B12 deficiency When a person receives treatment for a B12 deficiency, they generally recover well and cease to have symptoms, although they may need to continue to use B12 nutritional supplements
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These include how bad your deficiency is, how you react to treatment, and the method of injection
Community-reported effects (nausea, GI discomfort, headache) come only from anecdotal vendor/forum sources, not controlled studies
48 Chiu, Y.-W., Chang, J.-M., Hwang, S.-J., Tsai, J.-C