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Scientific investigations involving glutathione commonly explore: Oxidative stress response mechanisms Cellular antioxidant defense systems Detoxification pathway analysis Free radical research Mitochondrial function investigations Cellular signaling pathways Biochemical redox balance studies Work to investigate glutathione is proceeding in numerous disciplines ranging from molecular biology and toxicology to pharmacology and cellular biochemistry

Moreover, cancer cells carrying mutations of succinate dehydrogenase, fumarate hydrolase or isocitrate dehydrogenase accumulate -KG competitors including succinate, fumarate and 2-hydroxyglutarate, respectively 43,49,50

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