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When a compound has no completed human trial, there is by definition no safety data in any subgroup no pregnancy data, no hepatic-impairment data, no interaction data with common metabolic or endocrine medications

These may include issues related to intestinal permeability, irritation, or imbalance within the gut environment

3.3.2.1 Urolithin A Urolithin A, a natural gut metabolite of ellagic acid and ellagitannins, rich in nuts, is a safe mitophagy activator ( via promoting Nrf2 translocating into nucleus (Zhang et al., 2022c), but also ameliorates hyperuricemic nephropathy via enhancing PINK1-associated mitophagy in renal TECs (Zhang et al., 2022a)

Strict vegan diets lacking fortified foods provide insufficient B12, as the vitamin occurs naturally only in animal products

Wallace et al, 1989)