David recommends not taking metformin in the hours before a workout, or skipping it that day, because it can interfere with the bodys ability to make energy through mitochondria, reducing workout intensity and muscle gains
Lai S, Petramala L, Muscaritoli M, Cianci R, Mazzaferro S, Mitterhofer AP, Pasquali M, DAmbrosio V, Carta M, Ansuini M, Ramaccini C (2020) -Lipoic acid in patients with autosomal dominant polycystic kidney disease
[Abstract] J Funct Foods
Most athletes notice energy and clarity within the first two weeks
Human-focused reviews and meta-analyses have debated the magnitude and clinical relevance of lean mass changes during GLP-1RA therapy [41], whereas preclinical studies report context-dependent protection against muscle wasting [42, 43]