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Findings: RCTSTEP-HFpEF DM trial - Semaglutide vs Placebo in Obese Diabetics with HFpEF, NEJM (2024) [PubMed abstract] Design: Randomized, placebo-controlled trial (N=616 | length = 52 weeks) in obese type 2 diabetics (BMI 30) with HFpEF Treatment: Semaglutide titrated to 2.4 mg once weekly vs Placebo Primary outcome: Change from baseline in the Kansas City Cardiomyopathy Questionnaire clinical summary score (KCCQ-CSS

If symptoms persist beyond 48 hours or worsen, contact your pharmacist, GP or prescribing clinician for assessment

Together, choline, methionine, and inositol form the classical lipotropic triad for normal fat metabolism and hepatic lipid clearance.* Dandelion Root Extract 10:1 (Taraxacum officinale, 32mg) A 10:1 concentrated extract equivalent to 320mg of raw dandelion root per serving, supporting normal bile production, healthy bile flow from the liver and gallbladder, and normal hepatic function.* Celandine Stem/Leaf/Flower (Chelidonium majus, 152mg) Greater Celandine is a traditional European liver and bile-supportive botanical used in professional phytotherapy for supporting normal bile secretion and healthy hepatic function, contributing choleretic (bile-stimulating) activity to the formula's overall hepatic support profile.* Please note: Celandine (Chelidonium majus) is a potent liver botanical

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Taking an integrated genetic and physiological approach, we treated seedlings of B73 wildtype and aminocyclopropane-1-carboxylic acid synthase (ACS) 2/6 double mutant, a maize genotype which lacks an enzyme in the ethylene biosynthetic pathway and therefore produce less ethylene, with aminocyclopropane-1-carboxylic acid (ACC), a precursor of ethylene