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Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance

Results Responses on the VR-12 (n=1649) were found to be heterogenous and best represented by a 2-class model (Class proportions = 0.44, 0.56

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Then they randomized half to continue tirzepatide and half to switch to placebo for another 52 weeks (Aronne et al., JAMA 2024)

These are both rapid-acting insulins