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In M population, the decrease in cyclotide production under heavy metal stress may be explained the reallocation of resources towards other tolerance mechanisms (e.g., metal sequestration or callose production), while in NM population, the increase in cyclotide production suggests an inducible defense response to mitigate oxidative stress or cellular damage caused by heavy metals

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This is complicated further by other medications and supplements which may reduce thyroid hormone absorption if not taken at the correct time