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It serves as a cofactor for the methionine synthase enzyme, which transfers methyl groups to enable the regeneration of methionine from homocysteine

A multicenter trial of 390 patients with diabetes mellitus receiving insulin therapy who were randomized to receive metformin, 850 mg three times daily, or placebo assessed the risk of vitamin B 12 deficiency and low vitamin B 12 levels over four years

It is important to note that patients in this group usually exhibit normal cognitive function

7,8 Other rare causes of focused oral pigmentation are the nevocellular nevus and blue nevus

Microneedle delivery raises absorption from near-zero to clinically meaningful levels 3 , which is why the molecule pairs naturally with at-home microinfusion