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Claims that BPC-157 nasal spray targets the brain via the olfactory pathway are mechanistic extrapolations at best

[Abstract] Signal Transduct Target Ther

The FDA's Pharmacy Compounding Advisory Committee is reviewing whether BPC 157 presents significant safety risks and whether compounding pharmacies should be permitted to prepare it as a bulk substance

Structurally modified to reduce binding to IGF-binding proteins, IGF-1 LR3 may remain bioactive significantly longer than unmodified IGF-1 under experimental conditions, allowing for sustained receptor engagement and downstream pathway analysis